A 26-year-old man with culture-proven chancroid has no HIV infection and no known allergy to macrolides or cephalosporins. Which is an accepted first-line outpatient regimen?
- A Metronidazole 400 mg twice daily for 7 days
- B Benzathine penicillin 2.4 million units IM once
- C Azithromycin 1 g orally as a single dose ✓
- D Acyclovir 400 mg three times daily for 7 days
Correct answer: C. Azithromycin 1 g orally as a single dose
Explanation
Recommended regimens for Haemophilus ducreyi include azithromycin 1 g orally once, ceftriaxone 250 mg IM once, ciprofloxacin for 3 days, or erythromycin for 7 days. Benzathine penicillin treats syphilis, metronidazole covers anaerobes, and acyclovir covers HSV, none of which act against H. ducreyi.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.