Which of the following is the recommended first-line treatment for a non-pregnant adult with chancroid who has no contraindications to any antibiotic?
- A Benzathine penicillin 2.4 million units IM once
- B Azithromycin 1 g orally as a single dose ✓
- C Doxycycline 100 mg orally twice daily for 14 days
- D Acyclovir 400 mg orally three times daily for 7 days
Correct answer: B. Azithromycin 1 g orally as a single dose
Explanation
Chancroid caused by Haemophilus ducreyi is treated with azithromycin 1 g orally as a single dose or ceftriaxone 250 mg IM as a single dose. Benzathine penicillin treats syphilis, not chancroid. Doxycycline for 14 days is the regimen for lymphogranuloma venereum. Acyclovir is used for genital herpes. B useful point for exams: bubo resolution may lag behind ulcer healing, and fluctuant buboes need aspiration or incision rather than excision.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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