Which laboratory investigation should be routinely performed in every new case of vitiligo according to standard practice?

• A Serum antinuclear antibody titre
• B Serum vitamin B12 level
• C Thyroid function tests and thyroid autoantibodies ✓
• D Fasting blood glucose

Explanation

Vitiligo has the strongest documented association with autoimmune thyroid disease, so thyroid function tests and anti-thyroid peroxidase antibodies are recommended at baseline in all patients. Antinuclear antibodies are checked only if lupus is suspected clinically, and C12 deficiency, diabetes, and Addison disease are rarer associations screened selectively when symptoms suggest them.

Reference: Rook's Textbook of Dermatology, 9th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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