Kligman's original triple combination cream for melasma contained which three agents?
- A Hydroquinone 5%, tretinoin 0.1%, dexamethasone 0.1% ✓
- B Hydroquinone 2%, tretinoin 0.025%, hydrocortisone 1%
- C Hydroquinone 4%, kojic acid 1%, mometasone 0.1%
- D Hydroquinone 3%, adapalene 0.1%, fluocinolone 0.01%
Correct answer: A. Hydroquinone 5%, tretinoin 0.1%, dexamethasone 0.1%
Explanation
Kligman's formula, described in 1975, combined hydroquinone 5%, tretinoin 0.1%, and dexamethasone 0.1%. The commercial fixed combination later modified these strengths to hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.01%. Option B uses weaker concentrations than the original description, and options C and D substitute agents not part of Kligman's formulation.
Reference: Fitzpatrick's Dermatology, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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