A 28-year-old woman with extensive non-segmental vitiligo involving more than 80% of the body surface has failed repigmentation therapies. She requests removal of the remaining pigmented patches for a uniform appearance. Which agent is used for this purpose?
- A Methoxsalen with UVA
- B Topical tacrolimus 0.1%
- C Monobenzyl ether of hydroquinone ✓
- D Azelaic acid 20%
Correct answer: C. Monobenzyl ether of hydroquinone
Explanation
Monobenzyl ether of hydroquinone (monobenzone) is a permanent depigmenting agent reserved for extensive vitiligo exceeding 50% body surface area in patients who fail repigmentation. It destroys residual melanocytes and causes irreversible depigmentation, including at distant sites. Tacrolimus and PUVA are repigmentation modalities, and azelaic acid is used for hyperpigmentation, so none can achieve uniform depigmentation.
Reference: Rook's Textbook of Dermatology, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.