Which HLA allele shows the strongest association with type 1 (early-onset, familial) psoriasis?

• A HLA-DR4
• B HLA-B8
• C HLA-DQ2
• D HLA-Cw6 ✓

Explanation

HLA-Cw6, located within the PSORS1 susceptibility locus on chromosome 6p, carries the strongest known genetic association with psoriasis. Type 1 disease, defined by onset before 40 years, shows strong HLA-Cw6 linkage, greater familial clustering and more severe course. HLA-D27 is linked to axial psoriatic arthritis rather than susceptibility to cutaneous plaques, which kills that tempting distractor.

Reference: Rook's Textbook of Dermatology, 9th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.