A 40-year-old woman with psoriasis presents with fever, generalized skin erythema, and sheets of sterile pustules over the trunk. She had abruptly stopped systemic corticosteroids 5 days ago. What is this feared complication?
- A Erythrodermic psoriasis
- B Localized pustular psoriasis (palmoplantar)
- C Generalized pustular psoriasis (von Zumbusch type) ✓
- D Impetigo herpetiformis
Correct answer: C. Generalized pustular psoriasis (von Zumbusch type)
Explanation
Generalized pustular psoriasis (GPP) of the von Zumbusch type is a life-threatening form characterized by sudden onset of widespread erythema studded with sterile superficial pustules, accompanied by fever, leukocytosis, and systemic illness. Withdrawal of systemic corticosteroids is a classic trigger. The pustules are subcorneal collections of neutrophils forming Munro microabscesses and spongiform pustules of Kogoj. Erythrodermic psoriasis involves erythema and scaling over >90% of BSA without pustulation.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.