Paraneoplastic pemphigus carries a poor prognosis. Which underlying neoplasm is most commonly associated with paraneoplastic pemphigus in Western populations?
- A Thymoma
- B Castleman disease
- C Non-Hodgkin lymphoma / chronic lymphocytic leukemia ✓
- D Bronchogenic squamous cell carcinoma
Correct answer: C. Non-Hodgkin lymphoma / chronic lymphocytic leukemia
Explanation
Paraneoplastic pemphigus is most commonly associated with lymphoproliferative disorders. In Western populations, non-Hodgkin lymphoma and CLL account for the largest proportion. Thymoma is associated with myasthenia gravis and some pemphigus cases but less commonly with PNP. Castleman disease, especially multicentric form, is the most common association in some studies but NHL/CLL predominates overall.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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