In pemphigus vulgaris, the blister forms at which histological level?

• A Subcorneal
• B Subepidermal
• C Intraepidermal subcorneal granular layer
• D Intraepidermal suprabasal ✓

Explanation

Pemphigus vulgaris blister forms suprabasally (just above the basal layer) due to acantholysis of the spinous layer while the basal cells remain attached to the dermis in a 'tombstone' pattern. Pemphigus foliaceus blisters in the granular layer (subcorneal/granular). Bullous pemphigoid and DH are subepidermal. Subcorneal splitting is seen in IgA pemphigus and staphylococcal scalded skin syndrome.

Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.