Paraneoplastic pemphigus in an adult patient is most frequently associated with which underlying neoplasm?
- A Non-Hodgkin lymphoma and chronic lymphocytic leukaemia ✓
- B Renal cell carcinoma
- C Castleman disease
- D Thymoma
Correct answer: A. Non-Hodgkin lymphoma and chronic lymphocytic leukaemia
Explanation
Non-Hodgkin lymphoma and chronic lymphocytic leukaemia are the most frequent malignancies behind paraneoplastic pemphigus in adults, together accounting for the majority of cases. Castleman disease is the leading association in children and adolescents, which makes it a strong distractor but not the commonest cause overall in adults. Thymoma and other solid tumours account for a small minority. Any refractory pemphigus-like eruption with severe mucositis warrants a search for occult lymphoproliferative disease.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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