Epidemiological studies of bullous pemphigoid in elderly patients show a consistently strong association with which group of comorbidities?

• A Gluten-sensitive enteropathy
• B Neurodegenerative diseases such as dementia and parkinsonism ✓
• C Autoimmune thyroid disease
• D Inflammatory bowel disease

Explanation

Large cohort studies show bullous pemphigoid is significantly associated with neurological diseases, particularly dementia, Parkinson disease, stroke, and epilepsy, possibly through altered blood-brain barrier permeability exposing BP180-related neural antigens. Coeliac disease and dermatitis herpetiformis are linked together, not with bullous pemphigoid. Autoimmune thyroid disease clusters with vitiligo and other organ-specific autoimmunity rather than pemphigoid. Inflammatory bowel disease is associated with linear IgA bullous dermatosis and pyoderma gangrenosum instead.

Reference: Rook's Textbook of General Dermatology, 9th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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