A 60-year-old woman has superficial scaling and crusted plaques on the face and upper trunk resembling seborrheic dermatitis. She also has arthralgia, photosensitivity, and a positive antinuclear antibody. Biopsy shows subcorneal acantholysis with focal interface change. Which eponymous entity best fits this presentation?
- A Brunsting-Perry syndrome
- B Hallopeau-Siemens syndrome
- C Senear-Usher syndrome ✓
- D Gougerot-Carteaud syndrome
Correct answer: C. Senear-Usher syndrome
Explanation
Senear-Usher syndrome describes the overlap of pemphigus foliaceus with lupus erythematosus: seborrheic distribution of crusted lesions, positive antinuclear antibody, and histology showing subcorneal acantholysis with lupus-like interface changes. Brunsting-Perry refers to a localised scarring variant of mucous membrane pemphigoid affecting head and neck skin. Hallopeau-Siemens is a severe recessive dystrophic epidermolysis bullosa, unrelated to autoimmunity.
Reference: Bolognia, Schaffer and Cerroni, Dermatology, 5th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.