Dermatitis herpetiformis shows the strongest genetic association with which HLA alleles?
- A HLA-DR4 and HLA-DR14
- B HLA-DQ2 and HLA-DQ8 ✓
- C HLA-B27 and HLA-B51
- D HLA-DQB1*0301 and HLA-DRB1*0402
Correct answer: B. HLA-DQ2 and HLA-DQ8
Explanation
Like celiac disease, dermatitis herpetiformis is strongly linked to HLA-DQ2 (DQA1*0501/DQB1*0201) and, in DQ2-negative patients, HLA-DQ8. HLA-DR4 and DR14 are the classic associations of pemphigus vulgaris, especially in Jewish and Indian populations respectively. HLA-A27 relates to seronegative spondyloarthropathies and A51 to Behcet disease, neither of which is relevant here.
Reference: Rook's Textbook of Dermatology, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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