In epidermolysis bullosa acquisita (EBA), the target antigen and immunofluorescence salt-split skin pattern respectively are:

• A Collagen VII; dermal side ✓
• B Collagen XVII; epidermal side
• C Laminin-332; dermal side
• D BP230; epidermal side

Explanation

EBA is caused by IgG antibodies against collagen VII (anchoring fibrils at the sub-lamina densa zone). Salt-split skin places collagen VII on the dermal side, so IgG deposits are seen on the floor of the split. This contrasts with BP (epidermal-side deposits). EBA can be mechanobullous (trauma-triggered) or inflammatory (mimicking BP), and it has strong associations with inflammatory bowel disease, particularly Crohn's disease.

Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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