According to the Hanifin and Rajka criteria, which of the following is a major diagnostic criterion for atopic dermatitis?

• A Elevated serum IgE
• B White dermographism
• C Early age of onset
• D Typical morphology and distribution ✓

Explanation

The Hanifin and Rajka criteria list four major criteria for atopic dermatitis: pruritus, typical morphology and distribution, chronic or relapsing dermatitis, and personal or family history of atopy. Elevated serum IgE, white dermographism, and early age of onset are considered minor associated features, not major diagnostic criteria.

Reference: Rook's Textbook of Dermatology, 9th ed.

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