Eczema and Dermatitis (Contact, Atopic, Seborrhoeic) MCQs

Dermatology · 17 free questions with answers & explanations.

1. A 35-year-old nurse develops well-demarcated erythema, vesicles, and crusting on the dorsum of both hands after starting use of latex gloves. Patch testing shows a positive reaction to latex at 48 and 72 hours. What type of hypersensitivity is responsible?
2. A 6-month-old infant presents with intense itching, erythema, and weeping papules over the face and extensor surfaces of limbs. The mother has asthma. Serum IgE is markedly elevated. Which diagnostic criterion is most specific for this condition?
3. A healthcare worker develops hand eczema. Patch testing to the European baseline series is performed. A reaction showing erythema and vesicles at 96 hours (D4) but NOT at 48 hours (D2) indicates:
4. A 6-year-old child with severe atopic dermatitis has failed topical steroids and topical tacrolimus. Dupilumab is considered. The mechanism of action of dupilumab in AD is:
5. Patch testing for allergic contact dermatitis uses a specific concentration and vehicle to avoid false reactions. A patient is patch tested to potassium dichromate. The reading at 96 hours (D4) shows a vesicular reaction (+++) at the test site. The D4 reading is preferred over D2 (48 hours) for which allergen group?
6. Dupilumab, approved for moderate-to-severe atopic dermatitis, targets:
7. Patch testing is the gold standard for diagnosing allergic contact dermatitis. Which of the following statements about patch testing is CORRECT?
8. A 6-month-old infant presents with pruritic oozing eczema on the cheeks and extensor surfaces. Serum IgE is elevated. The filaggrin protein (FLG) gene mutation predisposes to atopic dermatitis primarily by:
9. A 25-year-old healthcare worker develops vesicles and erythema on the dorsum of both hands after wearing latex gloves. Patch testing at 48 and 96 hours shows a +++ reaction to thiuram mix but is negative for latex proteins. The type of hypersensitivity and the relevant component responsible are:
10. Dupilumab (anti-IL-4Rα) for moderate-to-severe atopic dermatitis achieves remission by blocking which specific cytokines?
11. Filaggrin gene (FLG) loss-of-function mutations are the strongest genetic risk factor for atopic dermatitis. Filaggrin deficiency leads to barrier impairment through which mechanism?
12. Patch testing for allergic contact dermatitis is performed with standardised concentrations in petrolatum. The reading is done at 48 hours AND 96 hours (4 days). Why is the 96-hour reading mandatory in addition to 48-hour reading?
13. Patch testing is performed for allergic contact dermatitis. A patient shows 2+ reaction at 72 hours to fragrance mix but not at 48 hours. The interpretation of this 'late positive' reaction is:
14. A 25-year-old atopic patient on dupilumab (anti-IL-4Rα) for moderate-to-severe atopic dermatitis develops bilateral non-infectious conjunctivitis. Which cytokine pathway is implicated in this adverse effect?
15. Allergic contact dermatitis (ACD) to nickel in a jewellery worker is being evaluated by patch testing. A +++ reaction means:
16. A hairdresser develops chronic eczema predominantly on the dorsal hands and fingertips that worsens at work and improves on holidays. She has a history of childhood atopic eczema. Patch testing shows positive reactions to para-phenylenediamine (PPD), thiuram mix, and nickel sulphate. This presentation represents:
17. The filaggrin (FLG) gene mutations found in atopic dermatitis (AD) patients affect epidermal barrier function. Which of the following best describes the downstream consequence of filaggrin deficiency that perpetuates the AD inflammatory cycle?