Which drug is the most frequently implicated agent in drug-induced Sweet syndrome?

• A Amoxicillin-clavulanate
• B Granulocyte colony-stimulating factor ✓
• C Hydrochlorothiazide
• D Carbamazepine

Explanation

Granulocyte colony-stimulating factor is the single most commonly reported trigger of drug-induced Sweet syndrome, consistent with the central role of neutrophil activation and cytokines such as G-CSF, IL-1, and IL-6 in its pathogenesis. Amoxicillin-clavulanate, hydrochlorothiazide, carbamazepine, trimethoprim-sulfamethoxazole, and minocycline have also been reported but far less frequently. Recognition matters because the eruption resolves after drug withdrawal and can be confused with leukaemia cutis in oncology patients receiving G-CSF.

Reference: Bolognia, Schaffer and Cerroni, Dermatology, 5th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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