Sweet's syndrome (acute febrile neutrophilic dermatosis) is MOST commonly associated with which type of underlying malignancy?
- A Solid tumours (lung, breast, colon)
- B Hodgkin lymphoma
- C Acute myeloid leukaemia ✓
- D Multiple myeloma
Correct answer: C. Acute myeloid leukaemia
Explanation
Malignancy-associated Sweet's syndrome is most commonly linked to acute myeloid leukaemia (AML), followed by other myeloproliferative and myelodysplastic disorders. This haematological association should prompt a bone marrow examination when Sweet's is suspected without an obvious infectious or drug cause. The cytokine milieu in AML (G-CSF, IL-1, IL-3) drives neutrophil activation. Solid tumours account for a smaller proportion. Importantly, Sweet's may precede, coincide with, or herald relapse of AML.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.