Anatomy · Neuroanatomy — Tracts, Nuclei and Lesion Localization (Advanced)

A patient with a midbrain lesion presents with ipsilateral oculomotor nerve palsy and contralateral intention tremor and ataxia (no hemiplegia). The red nucleus is involved. This is:

  • A Weber syndrome
  • B Benedikt syndrome
  • C Claude syndrome
  • D Nothnagel syndrome
Correct answer: B. Benedikt syndrome

Explanation

Benedikt syndrome results from a tegmental midbrain lesion involving the CN III nucleus/fascicles and the red nucleus. It produces ipsilateral CN III palsy and contralateral tremor/ataxia. Weber syndrome (cerebral peduncle) gives CN III palsy with contralateral hemiplegia. Claude syndrome involves CN III + superior cerebellar peduncle (contralateral ataxia without tremor). Nothnagel syndrome combines CN III palsy with cerebellar ataxia from superior peduncle damage.

Reference: BD Chaurasia's Human Anatomy, 8th ed.

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