Anatomy · Developmental Signalling and Molecular Embryology (HOX, SHH, Neural Crest)

Neural crest cells that migrate from the rhombomeres of the hindbrain contribute to the formation of:

  • A Bones of the viscerocranium (facial skeleton) and smooth muscle of pharyngeal arch arteries
  • B Dorsal root ganglia of spinal nerves and melanocytes only
  • C Bones of the neurocranium and meninges around the forebrain
  • D Myocardial cells of the ventricular septum and atrioventricular valves
Correct answer: A. Bones of the viscerocranium (facial skeleton) and smooth muscle of pharyngeal arch arteries

Explanation

Cranial neural crest cells (particularly from rhombomeres 1-8 of the hindbrain) are ectomesenchymal in nature and contribute to the viscerocranium (bones of the face and mandible), middle ear ossicles, cartilages of pharyngeal arches, smooth muscle of the aortic arch arteries (tunica media), dental pulp, and peripheral nerves of the head. The neurocranium is derived from both neural crest and paraxial mesoderm. Cardiac neural crest cells contribute to the outflow tract septum. Spinal DRG neurons arise from trunk neural crest, not cranial crest.

Reference: BD Chaurasia's Human Anatomy, 8th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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