Sugammadex produces reliable reversal of neuromuscular blockade produced by each of the following agents EXCEPT:

• A Rocuronium
• B Vecuronium
• C Pancuronium
• D Cisatracurium ✓

Explanation

Sugammadex is a modified gamma-cyclodextrin that encapsulates steroidal (aminosteroid) relaxants with a free amino group, namely rocuronium, vecuronium and pancuronium, though its affinity is far lower for pancuronium. Cisatracurium is a benzylisoquinolinium compound eliminated by Hofmann degradation, has no steroid backbone, and cannot be encapsulated, so sugammadex is ineffective against it.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.