Which anticholinesterase used for reversal of non-depolarising block has the SHORTEST duration of reversal action?
- A Neostigmine
- B Edrophonium ✓
- C Pyridostigmine
- D Physostigmine
Correct answer: B. Edrophonium
Explanation
Edrophonium acts by electrostatic binding rather than carbamylation of cholinesterase, giving a faster onset but shorter duration of about 60 minutes, so it can be outlasted by a long-acting relaxant such as pancuronium. Neostigmine lasts roughly 60 to 80 minutes with more reliable sustained reversal, and pyridostigmine lasts even longer. Physostigmine crosses the blood-brain barrier and is not used for neuromuscular reversal.
Reference: Miller's Anesthesia, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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