Among the following non-depolarising muscle relaxants, which has the LONGEST clinical duration of action at standard intubating doses?
- A Rocuronium
- B Vecuronium
- C Pancuronium ✓
- D Cisatracurium
Correct answer: C. Pancuronium
Explanation
Pancuronium is a long-acting aminosteroid with a clinical duration of roughly 60 to 100 minutes, compared with intermediate duration of 30 to 45 minutes for rocuronium, vecuronium and cisatracurium. Its long action results from slower clearance and greater protein binding. The trade-off is vagolysis-induced tachycardia, which the other three agents lack.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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