Endocrine Pharmacology MCQs

Pharmacology · 8 free questions with answers & explanations.

1. A 45-year-old type 2 diabetic with eGFR of 35 mL/min/1.73m² is on metformin. What is the MOST serious risk that mandates discontinuation of metformin at this eGFR?
2. Which insulin preparation has the LONGEST duration of action and has a relatively peakless, flat pharmacokinetic profile?
3. A patient with type 2 diabetes on metformin is started on a sulfonylurea. He presents 3 hours after a meal with sweating, tremors and a blood glucose of 42 mg/dL. Which sulfonylurea is MOST likely to cause this prolonged hypoglycaemia?
4. A SGLT2 inhibitor is prescribed for a type 2 diabetic with established cardiovascular disease. Besides glycaemic control, which additional benefit has been demonstrated in large cardiovascular outcome trials for this drug class?
5. Propylthiouracil (PTU) is preferred over carbimazole in which of the following clinical situations?
6. A postmenopausal woman is started on alendronate for osteoporosis. She is instructed to take it with a full glass of water and remain upright for 30 minutes. The MAIN reason for this instruction is to prevent:
7. A DPP-4 inhibitor (sitagliptin) exerts its antidiabetic effect primarily by:
8. Which combined oral contraceptive pill formulation poses the LOWEST risk of venous thromboembolism?