Neoplasia — Advanced Sub-topics MCQs

Pathology · 8 free questions with answers & explanations.

1. The Warburg effect describes a fundamental metabolic shift in cancer cells characterized by:
2. A tumor that expresses carcinoembryonic antigen (CEA) and CA 19-9 is most consistent with a malignancy arising from which tissue?
3. Which mechanism allows cancer cells to resist anoikis (apoptosis triggered by loss of cell-matrix contact), facilitating metastasis?
4. Which mechanism explains the phenomenon of 'oncogene addiction' seen in certain cancers such as BCR-ABL-driven CML or EGFR-mutant lung adenocarcinoma?
5. A patient develops fever, rigors, hemoglobinuria (dark urine), and acute hemolytic anemia after receiving a transfusion. The most likely cause is:
6. Hairy cell leukemia is a B-cell malignancy with characteristic hairy cytoplasmic projections. Which mutation is found in nearly all cases and is the target of vemurafenib?
7. Polycythemia vera (PV) is a myeloproliferative neoplasm. JAK2 V617F mutation is found in >95% of cases. What is the direct consequence of this mutation at the molecular level?
8. Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by granulomatous destruction of interlobular bile ducts. The diagnostic autoantibody is: