STDs, Leprosy & Syphilis MCQs

Dermatology · 6 free questions with answers & explanations.

1. A 28-year-old man presents with a painless, indurated, clean-based genital ulcer with a rubbery consistency. Inguinal lymphadenopathy is non-tender. Dark-field microscopy of serous fluid from the ulcer base shows actively motile, corkscrew-shaped organisms with characteristic end-flexion movements. Serology: VDRL reactive 1:32, TPHA positive. What is the stage and drug of choice?
2. A 30-year-old woman presents with painless, soft, flesh-coloured, cauliflower-like growths in the perianal region. On application of 5% acetic acid, the lesions turn white. PCR confirms high-risk HPV type 16. Which statement about this condition and its management is CORRECT?
3. A 35-year-old male farmer from Rajasthan presents with a 3-year history of anaesthetic hypopigmented patches on the trunk, thickening of the ulnar and great auricular nerves, and clawing of the 4th and 5th fingers of the left hand. Slit-skin smear (SSS) from the active edge of the lesion shows no AFB (BI = 0). What is the Ridley-Jopling classification and WHO MB/PB regimen applicable here?
4. A 26-year-old HIV-negative man presents with a painful, soft, non-indurated genital ulcer with undermined edges and a purulent base on the prepuce. Inguinal lymphadenopathy is unilateral and tender. Gram stain of pus shows small Gram-negative rods arranged in chains ('school of fish' or 'shoal of fish' pattern). What is the causative organism and recommended treatment?
5. A 32-year-old man presents with a painless papule on the glans that ulcerates and heals spontaneously. Two months later he develops a generalised maculopapular rash involving the palms and soles, mucous patches in the mouth, and condylomata lata in the perianal region. VDRL is reactive at 1:128. What distinguishes the condylomata lata seen here from condylomata acuminata caused by HPV?
6. A newborn presents on day 2 of life with a pemphigus-like bullous eruption involving the palms and soles, hepatosplenomegaly, and snuffles (seropurulent nasal discharge). The mother had untreated syphilis throughout pregnancy. Serology: baby's IgM-TPHA positive. What is this condition and the treatment?