A 68-year-old man with benign prostatic hyperplasia has a prostate of 50 grams on ultrasound and an IPSS score of 18. He is started on a medication that reduces prostate volume by inhibiting the conversion of testosterone to dihydrotestosterone. Which drug has this mechanism?
- A Finasteride ✓
- B Solifenacin
- C Tamsulosin
- D Tolterodine
Correct answer: A. Finasteride
Explanation
Finasteride is a 5-alpha reductase inhibitor that blocks conversion of testosterone to DHT, reducing prostate volume over months. It is indicated in BPH with enlarged prostate. Tamsulosin is an alpha-1 blocker that relaxes smooth muscle but does not reduce volume. Solifenacin and tolterodine are antimuscarinics used for overactive bladder, not BPH with obstruction.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.