A 55-year-old man with primary hyperparathyroidism undergoes focused parathyroidectomy for a single adenoma. Intraoperative PTH is measured. According to the Miami criterion, what percentage drop from the pre-excision baseline at 10 minutes confirms surgical cure?
- A 90%
- B 70%
- C 50% ✓
- D 30%
Correct answer: C. 50%
Explanation
The Miami criterion defines a surgical cure as a drop of 50% or more in intact PTH from the highest pre-excision level at 10 minutes after gland removal. This criterion has a sensitivity and specificity exceeding 95% for predicting cure. The Halle criterion uses a drop below 35 pg/mL at 15 minutes.
Reference: Schwartz's Principles of Surgery, 11th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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