In the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), a follicular neoplasm reported as Bethesda Category IV carries a malignancy risk of approximately:
- A 1–4%
- B 45–60%
- C 10–40% ✓
- D More than 90%
Explanation
Bethesda Category IV (Follicular Neoplasm / Suspicious for Follicular Neoplasm) carries a malignancy risk of approximately 10–40% in the revised 2017 TBSRTC classification (reflecting the reclassification of non-invasive follicular thyroid neoplasm with papillary-like nuclear features [NIFTP]). The standard management is a diagnostic hemithyroidectomy to allow histological assessment of capsular/vascular invasion — which cannot be determined by FNA cytology alone.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
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Written and medically reviewed by the StethoPrep medical team.