A trauma patient with massive haemorrhage has received 8 units of packed red blood cells in the last 2 hours. Point-of-care testing shows prolonged clotting with fibrinogen of 0.8 g/L (normal 2 to 4 g/L). Which blood product is specifically indicated to correct this abnormality?
- A Fresh frozen plasma 15 mL/kg
- B Prothrombin complex concentrate 25 IU/kg
- C Cryoprecipitate 1 to 2 units per 10 kg body weight ✓
- D Single-donor apheresis platelet unit
Correct answer: C. Cryoprecipitate 1 to 2 units per 10 kg body weight
Explanation
Fibrinogen below 1.0 g/L in massive haemorrhage is best corrected with cryoprecipitate, which is rich in fibrinogen, Factor VIII, and von Willebrand factor. FFP contains fibrinogen but in insufficient volume to rapidly correct severe hypofibrinogenaemia. European trauma guidelines recommend fibrinogen replacement when levels fall below 1.5 to 2.0 g/L.
Reference: Bailey and Love's Short Practice of Surgery, 28th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.