Which induction immunosuppressive agent is a non-depleting monoclonal antibody directed against the CD25 (IL-2 receptor alpha chain) expressed on activated T lymphocytes?
- A Antithymocyte globulin
- B Rituximab
- C Basiliximab ✓
- D Alemtuzumab
Correct answer: C. Basiliximab
Explanation
Basiliximab is a chimeric non-depleting anti-CD25 monoclonal antibody used as induction therapy in renal transplantation, targeting the IL-2 receptor alpha chain on activated T cells without depleting resting lymphocytes. Antithymocyte globulin and alemtuzumab are polyclonal and monoclonal depleting agents respectively, while rituximab targets CD20 on B cells. The distinction between depleting and non-depleting induction agents is the discriminating fact here.
Reference: Schwartz's Principles of Surgery, 11th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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