During procurement of a deceased donor kidney, the organ is flushed and stored in University of Wisconsin (UW) solution. Which component of this solution is responsible for providing the colloidal oncotic pressure that limits interstitial edema during cold storage?

• A Lactobionate
• B Adenosine
• C Glutathione
• D Hydroxyethyl starch ✓

Explanation

UW solution contains hydroxyethyl starch as its colloid, which exerts oncotic pressure and prevents interstitial edema during cold storage. Lactobionate and raffinose are impermeant anions and sugars that prevent cell swelling, glutathione acts as a free radical scavenger, and adenosine serves as a substrate precursor for ATP resynthesis on reperfusion. Knowing which ingredient does what distinguishes a student who has memorized the full composition from one who has not.

Reference: Sabiston Textbook of Surgery, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.