Sentinel lymph node biopsy (SLNB) uses blue dye and/or radioisotope (99mTc-sulfur colloid). The 'hot and blue' node concept identifies the sentinel node. What is the false-negative rate of SLNB in melanoma according to the MSLT-I trial?
- A Approximately 5–10% ✓
- B Less than 2%
- C 15–20%
- D 25–30%
Correct answer: A. Approximately 5–10%
Explanation
The Multicenter Selective Lymphadenectomy Trial (MSLT-I) established that SLNB in melanoma has a false-negative rate of approximately 5–10% when performed by experienced surgeons. A false-negative means the sentinel node biopsy is negative despite the presence of nodal metastases. The technique identifies the sentinel node correctly in >95% of cases (identification rate). A positive SLNB identifies patients who may benefit from completion lymph node dissection or adjuvant therapy.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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