Post-transplant lymphoproliferative disorder (PTLD) is most commonly associated with which viral infection and predominantly involves which cell type?

• A CMV; T lymphocytes
• B HHV-8; endothelial cells causing Kaposi sarcoma
• C BK virus; urothelial cells
• D EBV; B lymphocytes (EBV-driven B-cell proliferation in immunosuppressed recipient) ✓

Explanation

PTLD arises from EBV-driven B-cell proliferation under conditions of T-cell immunosuppression. In seronegative recipients receiving an EBV-positive organ, primary EBV infection drives unchecked B-cell expansion (EBV immortalizes B cells via LMP-1 and EBNA). Most cases (>80%) are of B-cell origin. Management involves reduction of immunosuppression as first step; rituximab (anti-CD20) for CD20+ B-cell PTLD; chemotherapy for high-grade lymphoma. HHV-8 causes Kaposi sarcoma. BK virus causes nephropathy in kidney transplant recipients. CMV causes systemic febrile illness and end-organ disease.

Reference: Bailey & Love's Short Practice of Surgery, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.