Which of the following congenital anomalies is a well-established strong risk factor for the development of gallbladder carcinoma even in the absence of gallstones?
- A Anomalous pancreaticobiliary ductal junction with a long common channel outside the sphincter of Oddi ✓
- B Pancreas divisum
- C Duodenal web
- D Annular pancreas
Correct answer: A. Anomalous pancreaticobiliary ductal junction with a long common channel outside the sphincter of Oddi
Explanation
Anomalous pancreaticobiliary junction allows pancreatic juice to reflux into the biliary tree because the union lies beyond sphincter control, producing chronic mucosal injury and a markedly increased risk of gallbladder carcinoma, classically in young patients without stones. Prophylactic cholecystectomy is advised once detected. Pancreas divisum, duodenal web, and annular pancreas are not linked to gallbladder malignancy.
Reference: Schwartz's Principles of Surgery, 11th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.