Which of the following conditions carries the highest attributable risk for the development of cholangiocarcinoma?
- A Dubin-Johnson syndrome
- B Gilbert syndrome
- C Primary sclerosing cholangitis ✓
- D Gallbladder polyp less than 5 mm
Correct answer: C. Primary sclerosing cholangitis
Explanation
Primary sclerosing cholangitis confers a lifetime cholangiocarcinoma risk of roughly 10 to 20 percent, the highest among common predisposing conditions, alongside chronic infection with liver flukes such as Opisthorchis viverrini in endemic areas. Gilbert and Dubin-Johnson syndromes are benign disorders of bilirubin handling with no malignant association. Small gallbladder polyps have negligible malignant potential and are unrelated to bile duct cancer.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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