Among cancers arising in the periampullary region, which primary tumour carries the best long-term survival after pancreaticoduodenectomy?
- A Pancreatic ductal adenocarcinoma
- B Distal cholangiocarcinoma
- C Ampullary carcinoma ✓
- D Duodenal adenocarcinoma
Correct answer: C. Ampullary carcinoma
Explanation
Ampullary carcinomas present earliest with jaundice because even small tumours obstruct the common channel, so they are diagnosed at low T stages, and their five-year survival after resection approaches 40 to 50 percent, the best among periampullary cancers. Pancreatic ductal adenocarcinoma has the worst outlook at roughly 20 percent. Distal cholangiocarcinoma and duodenal adenocarcinoma fall between these extremes.
Reference: Sabiston Textbook of Surgery, 21st ed.
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