The Lauren classification of gastric carcinoma divides it into intestinal and diffuse types. Krukenberg tumour specifically arises from which type, and what is the route of spread?
- A Intestinal type; haematogenous spread to ovaries
- B Diffuse type; transcoelomic spread via peritoneal seedlings
- C Diffuse type (signet ring); transperitoneal spread with mucinous ovarian deposits ✓
- D Both types equally; retrograde lymphatic spread
Correct answer: C. Diffuse type (signet ring); transperitoneal spread with mucinous ovarian deposits
Explanation
Krukenberg tumour is a bilateral ovarian metastasis classically from signet-ring cell gastric carcinoma (diffuse-type, Lauren classification). The predominant route is transperitoneal (transcoelomic) spread, although retrograde lymphatic and haematogenous routes also contribute. The signet-ring cells produce abundant mucin within the ovarian stroma, creating the characteristic gross and microscopic appearance. It carries a poor prognosis.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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