The FLOT regimen is the current preferred perioperative chemotherapy for resectable gastric and gastroesophageal junction (GEJ) adenocarcinoma based on the FLOT4 trial. What are its components?
- A 5-FU + leucovorin + oxaliplatin + docetaxel ✓
- B 5-FU + leucovorin + irinotecan + oxaliplatin
- C Epirubicin + cisplatin + capecitabine (ECX)
- D Cisplatin + 5-FU (CF regimen)
Correct answer: A. 5-FU + leucovorin + oxaliplatin + docetaxel
Explanation
The FLOT (5-Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel) regimen, used perioperatively (4 cycles before and 4 after surgery), demonstrated superior overall survival and pathological complete response rates compared to ECF/ECX in the FLOT4-AIO trial. It is now the standard of care for fit patients with resectable gastric or GEJ adenocarcinoma in Western guidelines, replacing ECF-based regimens.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
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