Pseudomyxoma peritonei (PMP) most commonly arises from a perforated mucinous appendiceal neoplasm. The PSOGI consensus classification of PMP distinguishes acellular mucin (grade 0) from which most aggressive histological subtype?
- A Disseminated peritoneal adenomucinosis (DPAM)
- B Peritoneal mucinous carcinomatosis (PMCA-I)
- C High-grade mucinous carcinoma peritonei with signet ring cells ✓
- D Low-grade mucinous carcinoma peritonei
Correct answer: C. High-grade mucinous carcinoma peritonei with signet ring cells
Explanation
The PSOGI (Peritoneal Surface Oncology Group International) 2016 classification of PMP grading: Grade 1 (low-grade) = disseminated peritoneal adenomucinosis (DPAM); Grade 2 (high-grade) = peritoneal mucinous carcinomatosis (PMCA); Grade 3 (high-grade with signet ring cells) = PMCA with signet ring cells, which carries the worst prognosis. Treatment is cytoreductive surgery (CRS) plus heated intraperitoneal chemotherapy (HIPEC), with outcomes dependent on completeness of cytoreduction and histological grade.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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