Amsterdam criteria II for hereditary non-polyposis colorectal cancer (Lynch syndrome) requires which of the following sets of conditions?
- A ≥3 relatives with colorectal cancer only, ≥2 successive generations, ≥1 diagnosed before age 45
- B ≥2 relatives with colorectal cancer and ≥1 with endometrial cancer at any age
- C ≥3 relatives with Lynch-associated cancer, ≥2 successive generations, ≥1 diagnosed before age 50, FAP excluded ✓
- D ≥3 relatives with any cancer, ≥1 diagnosed before age 50, MSI confirmed
Correct answer: C. ≥3 relatives with Lynch-associated cancer, ≥2 successive generations, ≥1 diagnosed before age 50, FAP excluded
Explanation
Amsterdam criteria II expanded on criteria I by including other Lynch-associated cancers (endometrial, ovary, stomach, small bowel, ureter/renal pelvis, brain, hepatobiliary, sebaceous skin tumours) beyond colorectal cancer. The criteria specify: ≥3 relatives with a Lynch-associated cancer, involving at least 2 successive generations, with at least 1 relative diagnosed before age 50, and familial adenomatous polyposis excluded. Amsterdam criteria I was limited only to colorectal cancer.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
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