The FOXTROT trial investigated which treatment strategy for locally advanced colon cancer?
- A Adjuvant oxaliplatin-based chemotherapy versus observation
- B Extended right hemicolectomy versus laparoscopic right hemicolectomy
- C Neoadjuvant chemotherapy before surgery versus upfront surgery ✓
- D Targeted therapy with bevacizumab added to FOLFOX for resectable colon cancer
Correct answer: C. Neoadjuvant chemotherapy before surgery versus upfront surgery
Explanation
The FOXTROT (Fluoropyrimidine, Oxaliplatin and Targeted Receptor Pre-Operative Therapy for Colon Cancer) trial evaluated neoadjuvant chemotherapy (FOLFOX/CAPOX) given before surgery versus direct surgery followed by adjuvant chemotherapy for locally advanced, resectable colon cancer. Results showed neoadjuvant chemotherapy led to tumor downstaging, reduced pT4 rate, improved R0 resection rates, and possibly improved recurrence-free survival without increasing surgical complications. This is changing the paradigm of colon cancer management toward a rectal-cancer model.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
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Written and medically reviewed by the StethoPrep medical team.