Histological examination of a dural-based intracranial tumour shows spindle cells arranged in concentric whorls with numerous lamellated basophilic calcified concretions. The tumour cells show strong immunoreactivity for EMA. What is the diagnosis?
- A Haemangiopericytoma (solitary fibrous tumour)
- B Psammomatous meningioma ✓
- C Schwannoma, Antoni A pattern
- D Calcifying pseudoneoplasm of the neuroaxis
Correct answer: B. Psammomatous meningioma
Explanation
Meningiomas are dural-based tumours of arachnoidal cap cells characterised by cellular whorls and strong EMA positivity; lamellated calcifications called psammoma bodies define the psammomatous subtype. Schwannoma is S100 positive and EMA negative, and shows Antoni A fascicles with Verocay bodies rather than whorls with psammoma bodies. Solitary fibrous tumour is CD34 and STAT6 positive, and calcifying pseudoneoplasm is a rare non-neoplastic lesion lacking whorled architecture.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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