The CREST syndrome (Calcinosis, Raynaud's, Esophageal dysmotility, Sclerodactyly, Telangiectasia) — a limited form of systemic sclerosis — is associated with which anti-nuclear antibody?
- A Anti-centromere antibodies (ACA) ✓
- B Anti-Scl-70 (anti-topoisomerase I)
- C Anti-dsDNA antibodies
- D Anti-Jo-1 antibodies
Correct answer: A. Anti-centromere antibodies (ACA)
Explanation
CREST syndrome/limited cutaneous systemic sclerosis is strongly associated with anti-centromere antibodies (ACA), present in 70–80% of patients. Anti-Scl-70 (anti-topoisomerase I) is associated with diffuse cutaneous systemic sclerosis, which has more severe interstitial lung disease and renal involvement. Anti-dsDNA is specific for SLE. Anti-Jo-1 is associated with polymyositis/antisynthetase syndrome. This distinction between limited vs diffuse scleroderma is a classic surgical/medicine NEET-PG oneliner.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.