A 6-year-old child presents with multiple fractures of varying ages. X-rays show generalized osteopenia, thin cortices, and wormian bones in the skull sutures. The most likely diagnosis is:

• A Osteopetrosis
• B Non-accidental injury
• C Osteogenesis imperfecta ✓
• D Fibrous dysplasia

Explanation

Osteogenesis imperfecta shows generalized osteoporosis, thin cortical bones, multiple fractures with exuberant callus, and pathognomonic wormian bones within cranial sutures. NAI would show fractures of different ages but would not have wormian bones or generalized osteopenia. Osteopetrosis shows uniformly dense bones (marble bone disease). Fibrous dysplasia shows ground-glass lesions, not diffuse osteoporosis.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.