A 60-year-old woman with long-standing dyspepsia undergoes barium meal examination. There is diffuse, symmetric narrowing of the entire stomach with loss of normal rugal folds, giving a rigid, non-distensible 'leather bottle' appearance. This finding is most characteristic of:

• A Ménétrier disease
• B Chronic hypertrophic gastritis
• C Gastric lymphoma
• D Linitis plastica ✓

Explanation

Linitis plastica (diffuse infiltrative gastric adenocarcinoma) classically produces a rigid, non-distensible stomach with loss of rugal folds, described as 'leather bottle stomach.' Ménétrier disease shows enlarged tortuous folds without rigidity. Gastric lymphoma shows thickened folds but a more distensible stomach. Hypertrophic gastritis causes fold thickening without the rigid 'leather bottle' appearance.

Reference: Gastrointestinal Radiology, Gore and Levine, 3rd ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.