Rameltean, used for sleep-onset insomnia, produces its therapeutic effect through which mechanism?

• A Positive modulation of the GABA-A receptor benzodiazepine site
• B Antagonism at histamine H1 receptors
• C Agonism at melatonin MT1 and MT2 receptors ✓
• D Inhibition of orexin receptors OX1 and OX2

Explanation

Ramelteon is a selective agonist at MT1 and MT2 melatonin receptors, shortening sleep onset latency without GABAergic effects. Its lack of benzodiazepine receptor activity explains why it carries no dependence liability and is not a scheduled drug. Orexin antagonists such as suvorexant and H1 antagonists act by different mechanisms entirely.

Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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