Which wakefulness-promoting agent is specifically approved for excessive sleepiness associated with shift work disorder?
- A Zolpidem
- B Modafinil ✓
- C Sodium oxybate
- D Clonazepam
Correct answer: B. Modafinil
Explanation
Modafinil improves alertness in shift work disorder by acting on dopaminergic signalling through weak DAT inhibition. Sodium oxybate is used in narcolepsy and taken at night, zolpidem is a hypnotic that promotes sleep rather than wakefulness, and clonazepam is a sedating benzodiazepine, so none addresses daytime sleepiness in shift workers.
Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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