Post-stroke depression is classically associated with infarction in which vascular territory or location?
- A Left anterior (frontal) region ✓
- B Right parietal cortex
- C Left occipital cortex
- D Cerebellar vermis
Correct answer: A. Left anterior (frontal) region
Explanation
Robinson's classical lesion studies linked post-stroke depression to left anterior lesions, particularly left dorsolateral prefrontal cortex and left basal ganglia, with severity correlating with proximity of the lesion to the frontal pole. Right hemisphere strokes were classically associated with indifference and euphoria rather than depression. Occipital and cerebellar lesions are not established sites for mood disorder after stroke.
Reference: Kaplan and Sadock's Synopsis of Psychiatry, 11th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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