Which psychiatric condition is the MOST common mental manifestation of hypothyroidism?
- A Depression with psychomotor retardation ✓
- B Panic disorder
- C Mania
- D Schizophreniform psychosis
Correct answer: A. Depression with psychomotor retardation
Explanation
Depression is the most frequent psychiatric presentation of hypothyroidism, typically with fatigue, psychomotor slowing, cold intolerance, weight gain, and cognitive dulling, so thyroid function testing is routine in the workup of new-onset depression. Anxiety states and panic are more characteristic of thyrotoxicosis. Mania is rare. Psychosis ('myxoedema madness') occurs but is distinctly uncommon compared with depressive presentations.
Reference: Kaplan and Sadock's Synopsis of Psychiatry, 11th ed.
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